Posttranscriptional Gene Regulation: RNA Processing in Eukaryotes

Reflecting the rapid progress in the field, the book presents the current understanding of molecular mechanisms of post-transcriptional gene regulation thereby focusing on RNA processing mechanisms in eucaryotic cells. With chapters on mechanisms as RNA splicing, RNA interference, MicroRNAs, RNA editing and others, the book also discusses the critical role of RNA processing for the pathogenesis of a wide range of human diseases. The interdisciplinary importance of the topic makes the title a useful resource for a wide reader group in science, clinics as well as pharmaceutical industry.Content:
Chapter 1 The Role of Cotranscriptional Recruitment of RNA?Binding Proteins in the Maintenance of Genomic Stability (pages 1–18): Jennifer A. Aoki and James L. Manley
Chapter 2 Transcription Termination by RNA Polymerase II (pages 19–40): Minkyu Kim and Stephen Buratowski
Chapter 3 Posttranscriptional Gene Regulation by an Editor: ADAR and its Role in RNA Editing (pages 41–81): Louis Valente, Yukio Kawahara, Boris Zinshteyn, Hisashi Iizasa and Kazuko Nishikura
Chapter 4 Posttranslational Modification of Sm Proteins: Diverse Roles in snRNP Assembly and Germ Line Specification (pages 83–116): Graydon B. Gonsalvez and A. Gregory Matera
Chapter 5 Structure, Function, and Biogenesis of Small Nucleolar Ribonucleoprotein Particles (pages 117–132): Katherine S. Godin and Gabriele Varani
Chapter 6 Mechanistic Insights into Mammalian Pre?mRNA Splicing (pages 133–161): Sebastian M. Fica, Eliza C. Small, Melissa Mefford and Jonathan P. Staley
Chapter 7 Splicing Decisions Shape Neuronal Protein Function across the Transcriptome (pages 163–180): Jill A. Dembowski and Paula J. Grabowski
Chapter 8 Noncoding RNA: The Major Output of Gene Expression (pages 181–213): Matthias Harbers and Piero Carninci
Chapter 9 Noncoding RNAs, Neurodevelopment, and Neurodegeneration (pages 215–238): Mengmeng Chen, Jianwen Deng, Mengxue Yang, Kun Zhu, Jianghong Liu, Li Zhu and Dr. Jane Y. Wu
Chapter 10 The Evolution of the Modern RNA World (pages 239–252): Ying Chen, Hongzheng Dai and Manyuan Long